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I kēia manawa, ke hoʻomohala nei ka ʻike kiʻi magnetic resonance (MRI) mai ke kiʻi hana kuʻuna a me ke kiʻi hana i ka kiʻi molecular. Multi-nuclear MR Hiki ke loaʻa i nā ʻike metabolite like ʻole i loko o ke kino o ke kanaka, ʻoiai e mālama ana i ka hoʻonā spatial, hoʻomaikaʻi i ka kikoʻī o ka ʻike ʻana i nā kaʻina hana physiological a me nā pathological, a ʻo ia wale nō ka ʻenehana hiki ʻole ke hoʻohālikelike quantitative ka nānā ʻana o ke kanaka dynamic molecular metabolism in vivo.

Me ka hohonu o ka MR Research multi-core, loaʻa iā ia nā manaʻo ākea ākea i ka nānā mua ʻana a me ka hōʻoia ʻana o nā ʻōpū, nā maʻi cardiovascular, nā maʻi neurodegenerative, nā ʻōnaehana endocrine, nā ʻōnaehana digestive a me nā maʻi ʻōnaehana hanu, a me ka loiloi wikiwiki o ke kaʻina hana. E kōkua ka papahana noiʻi lapaʻau multi-core hou loa o Philips i ke kiʻi kiʻi a me nā kauka lapaʻau e hoʻokō i ka noiʻi lapaʻau ʻokiʻoki. Ua hāʻawi ʻo Kauka Sun Peng lāua ʻo Dr. Wang Jiazheng mai Philips Clinical and Technical Support Department i kahi hoʻolauna kikoʻī i ka hoʻomohala ʻoki ʻana o multi-NMR a me ke kuhikuhi noiʻi o Philips hou multi-core MR Platform.

Ua lanakila ʻo Magnetic resonance i ka makana no ka Nobel i ʻelima mau manawa i loko o kona mōʻaukala, ma waena o nā kahua o ka physics, chemistry, biology, a me ka lāʻau lapaʻau, a ua loaʻa i ka lanakila nui ma nā kumu physics kumu, ka hoʻolālā molekula organik, ka dinamika macromolecular structure biological, a me ke kiʻi lāʻau lapaʻau. I waena o lākou, ua lilo ka magnetic resonance imaging i kekahi o nā ʻenehana loea lapaʻau koʻikoʻi nui, i hoʻohana nui ʻia i ka ʻike ʻana i nā maʻi like ʻole i nā ʻāpana like ʻole o ke kino kanaka. Me ka hoʻomau mau ʻana o nā pono mālama olakino, ʻo ke koi nui no ka maʻi maʻi mua a me ka loiloi efficacy wikiwiki e hāpai ana i ka hoʻomohala ʻana i ke kiʻi magnetic resonance mai ke kiʻi kuʻuna kuʻuna (T1w, T2w, PDw, a me nā mea ʻē aʻe), ke kiʻi hana (DWI, PWI, etc.)

ʻO ka ʻaoʻao paʻakikī o 1H ma muli o MR Technology, overlapping spectra, a me ka wai/momona compression i kaupalena ʻia kona wahi ma ke ʻano he ʻenehana kiʻi molecular. Hiki ke ʻike ʻia he helu palena wale nō o nā mole (choline, creatine, NAA, a me nā mea ʻē aʻe), a paʻakikī ke loaʻa i nā kaʻina metabolic molecular dynamic. Ma muli o nā ʻano nuclides (23Na, 31P, 13C, 129Xe, 17O, 7Li, 19F, 3H, 2H), multi-nuclear MR Hiki ke kiʻi i nā ʻike metabolite like ʻole o ke kino kanaka, me ka hoʻonā kiʻekiʻe a me ka kikoʻī kiʻekiʻe, a ʻo ia wale nō ka non-invasive, ʻaʻohe radioactivity radioactivity. (glucose, amino acids, fatty acids – non-toxic) no ka hoʻopaʻa ʻana i ka nui o nā kaʻina metabolic molecular dynamic kanaka.

Me ka hoʻomau mau ʻana i ka ʻōnaehana mīkini resonance magnetic, ke kaʻina hana wikiwiki (Multi-Band, Spiral) a me ka algorithm acceleration (compressed sensing, deep learning), multi-core MR Imaging/spectroscopy: (1) ua manaʻo ʻia e lilo ia i mea koʻikoʻi no ka ʻoki ʻana i ka molecular biology, biochemistry a me ka noiʻi metabolism kanaka; (2) I kona neʻe ʻana mai ka noiʻi ʻepekema i ka hoʻomaʻamaʻa lapaʻau (he nui o nā hoʻokolohua lapaʻau e pili ana i ka multi-core MR Are in progress, FIG. 1), loaʻa iā ia nā manaʻo ākea i ka nānā mua ʻana a me ka hōʻoia ʻana o ka maʻi kanesa, cardiovascular, neurodegenerative, digestive and respiratory maʻi, a me ka loiloi efficacy wikiwiki.

Ma muli o ka paʻakikī o ke kino a me ka paʻakikī ʻenehana kiʻekiʻe o ka MR Field, multi-core MR He wahi noiʻi kūʻokoʻa o kekahi mau keʻena noiʻi ʻenekinia kiʻekiʻe. ʻOiai ua holomua nui ʻo multicore MR ma hope o nā makahiki he nui o ka hoʻomohala ʻana, aia nō ka nele o ka ʻikepili lapaʻau kūpono e holomua i kēia kahua e lawelawe maoli i nā maʻi.

Ma muli o ka hoʻomau mau ʻana i ka hana o MR, ua uhaʻi hope ʻo Philips i ka bottleneck hoʻomohala o multi-core MR A ua hoʻokuʻu i kahi kahua noiʻi lapaʻau hou me nā nuclides i ka ʻoihana. ʻO ka paepae wale nō ka ʻōnaehana multi-core ma ka honua e loaʻa i ka EU Safety Conformity Certification (CE) a me ka US Food and Drug Administration (FDA), e hiki ai i kahi huahana-level full-stack multi-core MR Solution: FDA-approved coils, full sequence coverage, and operator station standard reconstruction. ʻAʻole pono e hoʻolako ʻia nā mea hoʻohana me nā physicists magnetic resonance, code engineers a me RF gradient designs, ʻoi aku ka maʻalahi ma mua o ka spectroscopy/kiʻi kiʻi 1H kuʻuna. Hoʻonui i ka hōʻemi ʻana o nā kumukūʻai hana MR nui, hoʻololi manuahi ma waena o ka noiʻi ʻepekema a me ke ʻano lapaʻau, ka wikiwiki o ka hoʻihoʻi ʻana i ke kumu kūʻai, i hiki ai i ka multi-core MR ʻoiaʻiʻo i ke keʻena.

ʻO Multi-core MR ʻO ia ke kuhikuhi nui o ka "14th Five-Year Medical Equipment Industry Development Plan", a he ʻenehana koʻikoʻi no ke kiʻi lāʻau lapaʻau e wāwahi i ka hana maʻamau a hui pū me ka biomedicine ʻokiʻoki. ʻO ka hui ʻepekema ʻo Philips Kina, i alakaʻi ʻia e ka hoʻomaikaʻi ʻana i ka noiʻi ʻepekema o nā mea kūʻai aku a me nā mana hou, alakaʻi i ka noiʻi ʻōnaehana ma ka multi-core MR. Kauka Sun Peng, Kauka Wang Jiazheng et al. mua i manaʻo i ka manaʻo o MR-nucleomics ma NMR ma Biomedicine (top Journal of the First Region of Spectroscopy of Chinese Academy of Science), hiki ke hoʻohana iā MR Ma muli o nā nuclides like ʻole e nānā i nā ʻano hana cell a me nā kaʻina pathological. No laila, hiki ke hoʻoholo a me ka loiloi piha ʻana i ka maʻi a me ka mālama ʻana [1]. ʻO ka manaʻo o MR Multinucleomics ka alakaʻi o ka MR Development. ʻO kēia pepa ka loiloi ʻōnaehana mua o ka multi-core MR I ka honua, e uhi ana i ke kumu kumu o ka multi-core MR, ka noiʻi pre-clinical, ka hoʻololi ʻana i ke kino, ka hoʻomohala ʻana i nā lako, ka holomua algorithm, ka hana ʻenekinia a me nā mea ʻē aʻe (Figure 2). Ma ka manawa like, ua hui pū ka hui o nā ʻepekema me Professor Song Bin o West China Hospital e hoʻopau i ka ʻatikala loiloi mua e pili ana i ka hoʻololi ʻana o ka MR multi-core ma Kina, i paʻi ʻia ma ka puke pai Insights into Imaging [2]. ʻO ka paʻi ʻia ʻana o nā ʻatikala ma multicore MR Hōʻike ʻia e lawe maoli ʻo Philips i ka palena o ke kiʻi molecular multicore i Kina, i nā mea kūʻai aku Kina, a i nā poʻe maʻi Kina. Ma ka laina me ka manaʻo kumu o "ma Kina, no Kina", e hoʻohana ʻo Philips i ka multi-core MR No ka hoʻolaha ʻana i ka hoʻomohala ʻana o ka resonance magnetic o Kina a kōkua i ke kumu o ke olakino Kina.

ʻO Multi-nuclear MRI kahi ʻenehana hou. Me ka hoʻomohala ʻana o MR Software and hardware, multi-nuclear MRI i hoʻohana ʻia i ka noiʻi unuhi kumu a me ka noiʻi o nā ʻōnaehana kanaka. ʻO kāna pono kūʻokoʻa ʻo ia ka hiki ke hōʻike i nā kaʻina metabolic hoʻoikaika i ka manawa maoli i nā kaʻina pathological like ʻole, no laila e hāʻawi ana i nā hiki no ka ʻike mua ʻana i nā maʻi, ka loiloi efficacy, ka hoʻoholo ʻana i ka mālama ʻana a me ka hoʻomohala ʻana i ka lāʻau. Hiki ke kōkua i ka ʻimi ʻana i nā hana hou o ka pathogenesis.

I mea e hoʻoikaika ai i ka hoʻomohala hou ʻana o kēia kahua, pono ke komo ʻana o nā loea lapaʻau. He mea koʻikoʻi ka hoʻomohala ʻana i ka clinicalization o nā platform multicore, me ke kūkulu ʻana i nā ʻōnaehana kumu, ka standardization o nā ʻenehana, ka helu ʻana a me ka hoʻohālikelike ʻana i nā hopena, ka ʻimi ʻana i nā probes hou, ka hoʻohui ʻana o nā ʻike metabolic he nui, a me nā mea ʻē aʻe, i ka hoʻomohala ʻana i nā hoʻokolohua multicenter hou aʻe, i mea e hoʻoikaika hou ai i ka hoʻololi ʻana o ka ʻenehana multicore MR. Manaʻo paʻa mākou e hāʻawi ʻo MR multi-core i kahi ākea ākea no nā kiʻi kiʻi a me nā loea lapaʻau e hana i ka noiʻi lāʻau lapaʻau, a e pōmaikaʻi kāna mau hopena i nā poʻe maʻi a puni ka honua.