nūhou

Hiki ke hōʻiliʻili ʻia nā laʻana kiko mai ka poʻe olakino e holomua i ka holomua olakino?

Pehea e hana ai i kahi kaulike ma waena o nā pahuhopu ʻepekema, nā pilikia kūpono, a me nā pono o nā mea komo?

I ka pane ʻana i ke kāhea no ka lāʻau lapaʻau pololei, ua neʻe kekahi mau ʻepekema lapaʻau a me nā kumu ʻepekema mai ka loiloi ʻana i nā hana i palekana a maikaʻi hoʻi no ka hapa nui o nā maʻi i kahi ala hoʻomaʻemaʻe e pili ana i ka ʻimi ʻana i ka lāʻau kūpono no ka mea maʻi kūpono i ka manawa kūpono. ʻO nā holomua ʻepekema, i hoʻokumu mua ʻia i ke kahua o ka oncology, ua hōʻike ʻia e hiki ke hoʻokaʻawale ʻia nā papa lapaʻau i loko o nā molecular intrinsic phenotypes, me nā alahele like ʻole a me nā pane therapeutic like ʻole. No ka wehewehe ʻana i nā hiʻohiʻona o nā ʻano cell like ʻole a me nā ʻano pathological, ua hoʻokumu nā ʻepekema i nā palapala kiko.

No ka hoʻolaha ʻana i ka noiʻi ʻana i ka maʻi maʻi kīpē, ua mālama ka National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) i kahi papa hana ma 2017 ʻO nā poʻe i komo i loko o nā ʻepekema kumu, nā nephrologists, nā mea hoʻoponopono federal, nā noho o ka Institutional Review Board (IRB), a ʻo ka mea nui loa, nā maʻi. Kūkākūkā nā lālā o ka seminar i ka waiwai ʻepekema a me ka ʻae ʻia ʻana o nā biopsies kidney i ka poʻe pono ʻole iā lākou i ka mālama lapaʻau no ka mea lawe lākou i kahi pilikia liʻiliʻi akā maopopo ka make. Hiki ke hoʻohana ʻia nā ʻenehana "omics" o kēia manawa (nā ʻano noiʻi molekula e like me genomics, epigenomics, proteomics, a me metabolomics) i ka nānā ʻana i nā kiko e wehewehe i nā ala maʻi i ʻike ʻole ʻia a ʻike i nā pahuhopu hiki ke hoʻopili i ka lāʻau. Ua ʻae ka poʻe i komo e ʻae wale ʻia nā biopsies kidney no nā kumu noiʻi wale nō, ke kaupalena ʻia lākou i nā pākeke nāna e ʻae, maopopo i nā pilikia a ʻaʻohe makemake pilikino, ʻo ka ʻike i loaʻa e hoʻohana ʻia e hoʻomaikaʻi i ka maikaʻi o ka maʻi a me ka ʻike ʻepekema, a ʻo ke kino loiloi, ka IRB, ʻae i ka noiʻi.

Ma hope o kēia ʻōlelo aʻoaʻo, i ka mahina ʻo Kepakemapa 2017, ua hoʻokumu ka NIDDK-funded Kidney Precision Medicine Project (KPMP) i ʻeono mau wahi hoʻopaʻa inoa e hōʻiliʻili i ka ʻiʻo mai nā maʻi me ka maʻi kīkī i loaʻa ʻole kahi hōʻailona o ka biopsy clinical. He 156 mau biopsies i hana ʻia i loko o nā makahiki ʻelima mua o ke aʻo ʻana, me 42 i nā poʻe maʻi me ka hōʻeha ʻeha ʻeha a me 114 i nā maʻi me ka maʻi maʻi maʻi. ʻAʻohe make, a ʻo nā pilikia e pili ana i ka hōʻailona a me ke koko asymptomatic i kūlike me nā mea i wehewehe ʻia ma nā palapala a me nā palapala ʻae noiʻi.

Hoʻopuka ka noiʻi ʻo Omics i kahi nīnau ʻepekema koʻikoʻi: Pehea ka hoʻohālikelike ʻana o ka ʻiʻo i hōʻiliʻili ʻia mai nā maʻi me ka ʻiʻo "maʻamau" a me ka "reference"? Ke hāpai nei kēia nīnau ʻepekema i kahi nīnau koʻikoʻi koʻikoʻi. ʻAʻole i kaupalena ʻia kēia nīnau i ka noiʻi ʻana i ka maʻi kīkī. ʻO ka hōʻiliʻili ʻana i nā ʻiʻo kuhikuhi olakino hiki ke holomua i ka noiʻi ʻana i nā ʻano maʻi. Akā ʻokoʻa nā pilikia e pili ana i ka hōʻiliʻili ʻana i nā ʻiʻo mai nā ʻāpana like ʻole ma muli o ka hiki ke komo ʻana o ke kino.